The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis

Lijun Mu; Enxu Xie; Xinwei Zhang; Juanhua Tian; Meiyu Wang; Dapeng Wu; Yuefeng Du

doi:doi:10.11648/j.ajls.20210905.16

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The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis

Lijun Mu, Enxu Xie, Xinwei Zhang, Juanhua Tian, Meiyu Wang, Dapeng Wu, Yuefeng Du

Published in American Journal of Life Sciences (Volume 9, Issue 5)

Received: 6 October 2021 Accepted: 30 October 2021 Published: 5 November 2021

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Abstract

OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.

Published in	American Journal of Life Sciences (Volume 9, Issue 5)
DOI	10.11648/j.ajls.20210905.16
Page(s)	141-148
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

OnabotulinumtoxinA, Overactive Bladder, Dosages

References

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APA Style

Lijun Mu, Enxu Xie, Xinwei Zhang, Juanhua Tian, Meiyu Wang, et al. (2021). The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. American Journal of Life Sciences, 9(5), 141-148. https://doi.org/10.11648/j.ajls.20210905.16

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ACS Style

Lijun Mu; Enxu Xie; Xinwei Zhang; Juanhua Tian; Meiyu Wang, et al. The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. Am. J. Life Sci. 2021, 9(5), 141-148. doi: 10.11648/j.ajls.20210905.16

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AMA Style

Lijun Mu, Enxu Xie, Xinwei Zhang, Juanhua Tian, Meiyu Wang, et al. The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. Am J Life Sci. 2021;9(5):141-148. doi: 10.11648/j.ajls.20210905.16

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@article{10.11648/j.ajls.20210905.16,
  author = {Lijun Mu and Enxu Xie and Xinwei Zhang and Juanhua Tian and Meiyu Wang and Dapeng Wu and Yuefeng Du},
  title = {The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis},
  journal = {American Journal of Life Sciences},
  volume = {9},
  number = {5},
  pages = {141-148},
  doi = {10.11648/j.ajls.20210905.16},
  url = {https://doi.org/10.11648/j.ajls.20210905.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20210905.16},
  abstract = {OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.},
 year = {2021}
}

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TY  - JOUR
T1  - The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis
AU  - Lijun Mu
AU  - Enxu Xie
AU  - Xinwei Zhang
AU  - Juanhua Tian
AU  - Meiyu Wang
AU  - Dapeng Wu
AU  - Yuefeng Du
Y1  - 2021/11/05
PY  - 2021
N1  - https://doi.org/10.11648/j.ajls.20210905.16
DO  - 10.11648/j.ajls.20210905.16
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 141
EP  - 148
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20210905.16
AB  - OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.
VL  - 9
IS  - 5
ER  -

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Author Information

Lijun Mu

Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Enxu Xie

Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Xinwei Zhang

Department of Urology, Xi'an Children’s Hospital, Xi'an, China
Juanhua Tian

Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Meiyu Wang

Department of Imaging, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Dapeng Wu

Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Yuefeng Du

Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

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APA Style

Lijun Mu, Enxu Xie, Xinwei Zhang, Juanhua Tian, Meiyu Wang, et al. (2021). The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. American Journal of Life Sciences, 9(5), 141-148. https://doi.org/10.11648/j.ajls.20210905.16

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ACS Style

Lijun Mu; Enxu Xie; Xinwei Zhang; Juanhua Tian; Meiyu Wang, et al. The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. Am. J. Life Sci. 2021, 9(5), 141-148. doi: 10.11648/j.ajls.20210905.16

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AMA Style

Lijun Mu, Enxu Xie, Xinwei Zhang, Juanhua Tian, Meiyu Wang, et al. The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis. Am J Life Sci. 2021;9(5):141-148. doi: 10.11648/j.ajls.20210905.16

Copy | Download

@article{10.11648/j.ajls.20210905.16,
  author = {Lijun Mu and Enxu Xie and Xinwei Zhang and Juanhua Tian and Meiyu Wang and Dapeng Wu and Yuefeng Du},
  title = {The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis},
  journal = {American Journal of Life Sciences},
  volume = {9},
  number = {5},
  pages = {141-148},
  doi = {10.11648/j.ajls.20210905.16},
  url = {https://doi.org/10.11648/j.ajls.20210905.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20210905.16},
  abstract = {OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - The Efficacy and Safety of OnabotulinumtoxinA with Different Dosages for the Treatment of Overactive Bladder Syndrome: A Systematic Review and Meta-analysis
AU  - Lijun Mu
AU  - Enxu Xie
AU  - Xinwei Zhang
AU  - Juanhua Tian
AU  - Meiyu Wang
AU  - Dapeng Wu
AU  - Yuefeng Du
Y1  - 2021/11/05
PY  - 2021
N1  - https://doi.org/10.11648/j.ajls.20210905.16
DO  - 10.11648/j.ajls.20210905.16
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 141
EP  - 148
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20210905.16
AB  - OnabotulinumtoxinA therapy has become widely used in overactive bladder syndrome (OAB), and many relevant articles have been published, however, there is no consensus regarding the clinical effect of onabotulinumtoxinA with the different dosages. Therefore, we conducted this meta-analysis to assess the efficacy and safety of 100 U, 200 U and 300 U onabotulinumtoxinA for the treatment of (OAB). In this project, We performed a comprehensive literature search, which was performed using EMBASE, PubMed, Cochrane database, and Google Scholar for randomized controlled trials (from inception to February 2017). As a result, fourteen studies with 1999 participants were selected. For the efficacy, 200 U of OnabotulinumtoxinA was significantly superior to 100 U, especially in the maximum cystometric capacity (MCC) and maximum detrusor pressure (MDP). Also, its subjective cure rate showed the same tendency. There were no statistical differences between 200 U and 300 U in MCC, MDP and subjective cure rate. For the adverse events, there were no statistical differences among 100 U, 200 U and 300 U OnabotulinumtoxinA in urinary tract infection (UTI) and urinary retention. Therefore, in our study. Compared to 100 U OnabotulinumtoxinA, 200 U OnabotulinumtoxinA has better efficacy while maintaining safety. Although 200 U OnabotulinumtoxinA is comparable to 300 U OnabotulinumtoxinA in terms of safety and efficacy, 200 U OnabotulinumtoxinA is a cost-effective intervention and may appear to be the optimal dosage for OAB populations.
VL  - 9
IS  - 5
ER  -

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