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Volume 8 , Issue 6 , December 2020 , Pages: 183 - 188
Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon
Md Shihab Uddin Sohag, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh; Beximco Pharmaceuticals Ltd., Gazipur, Bangladesh
Mst. Mahfuza Rahman, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh; Department of Pharmacy, Comilla University, Comilla, Bangladesh
Mollika Paul, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
Md. Masud Rana, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
Ranjan Kumar Barman, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
Mir Imam Ibne Wahed, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
Md. Rafiqul Islam Khan, Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh
Received: Jan. 13, 2020;       Accepted: Jan. 27, 2020;       Published: Nov. 23, 2020
DOI: 10.11648/j.ajls.20200806.11        View        Downloads  
Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both L. acidophilus and L. bulgaricus for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications.
Probiotics, Inflammatory Bowel Diseases, Acetic Acid-induced Inflammation
To cite this article
Md Shihab Uddin Sohag, Mst. Mahfuza Rahman, Mollika Paul, Md. Masud Rana, Ranjan Kumar Barman, Mir Imam Ibne Wahed, Md. Rafiqul Islam Khan, Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon, American Journal of Life Sciences. Vol. 8, No. 6, 2020, pp. 183-188. doi: 10.11648/j.ajls.20200806.11
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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